Schedule of Events | Symposia

Hippocampal – control network functional connectivity differentially predicts memory in young and older adults

Poster Session C - Sunday, March 30, 2025, 5:00 – 7:00 pm EDT, Back Bay Ballroom/Republic Ballroom

Troy Houser¹ (thouser@uoregon.edu), Caitlin R. Bowman, Dagmar Zeithamova; ¹University of Oregon, ²University of Wisconsin-Milwaukee, ³1

The executive control network in the brain has been hypothesized to serve as a compensatory mechanism for impaired memory in older adults. Here, we tested the extent to which control network’s resting state connectivity with the hippocampus, a central hub for memory, predicts memory ability in young and older adults. Participants completed category learning and recognition tasks using the same stimuli, providing measures of memory specificity and generalization ability. We found that hippocampal connectivity with the control network predicted memory specificity in both young and older adults. In contrast, hippocampal-control network connectivity predicted generalization ability in older adults only. The results open new avenues for inquiry about how hippocampal interactions at the network level support multiple memory functions in older adults.

Topic Area: LONG-TERM MEMORY: Episodic